Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are
the most frequent known genetic risk factor for Parkinson's disease. Reduced …

Mounting evidence suggests a role for autophagy dysregulation in Parkinson's disease
(PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …

Evidence from human postmortem material, transgenic mice, and cellular/animal models of
PD link alpha‐synuclein accumulation to alterations in the autophagy lysosomal pathway …