Highlights•The majority of proteins encoded in a genome are accessible by structure
modelling.•Modelling can provide accurate target predictions for structure-based drug …

The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …

The refinement and validation of a crystallographic structure model is the last step before the
coordinates and the associated data are submitted to the Protein Data Bank (PDB). The …

The structure of the human gut microbiota is controlled primarily through the degradation of
complex dietary carbohydrates, but the extent to which carbohydrate breakdown products …

We present a series of databanks (http://swift. cmbi. ru. nl/gv/facilities/) that hold information
that is computationally derived from Protein Data Bank (PDB) entries and that might …

Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand
breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and …

The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal
tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The …

Figure 1 N-glycan D-pyranosides in high-energy conformations, as deposited in the PDB
(left), and their corrected counterparts (right). Gray mesh, omit mFo–DFc density contoured …

RNA polymerase II-like enzymes carry out transcription of genomes in Eukaryota, Archaea,
and some viruses. They also exhibit fundamental similarity to RNA polymerases from …

Biological aging can be described as accumulative, prolonged metabolic stress and is the
major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified …