Duplicating a genome of 3 billion nucleotides is challenged by a variety of obstacles that can
cause replication stress and affect the integrity of the genome. Recent studies show that …

Aneuploidy, a deviation from the normal chromosome copy number, is common in human
embryos and is considered a primary cause of implantation failure and early pregnancy loss …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

Mammalian preimplantation embryos often contend with aneuploidy that arose either by the
inheritance of meiotic errors from the gametes, or from mitotic mis-segregation events that …

DNA replication in differentiated cells follows a defined program, but when and how it is
established during mammalian development is not known. Here we show using single-cell …

In assisted reproductive technology (ART)-derived embryos of non-rodent mammals,
including humans and cattle, chromosome segregation errors are highly likely to occur …

Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages.
For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos. However …

IVF embryos have historically been evaluated by morphological characteristics. The time-
lapse system (TLS) has become a promising tool, providing an uninterrupted evaluation of …

Aneuploidy is one of the main causes of miscarriage and in vitro fertilization failure. Mitotic
abnormalities in preimplantation embryos are the main cause of mosaicism, which may be …

Background Mitosis maintains a genome's genetic information in daughter cells by
accurately segregating chromosomes. However, chromosome aberrations are common …