Drug resistance and tolerance in fungi

J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

Changes in the epidemiological landscape of invasive candidiasis

F Lamoth, SR Lockhart, EL Berkow… - Journal of …, 2018 - academic.oup.com
The epidemiology of invasive candidiasis has evolved in recent years, warranting a review
of the changes and the implications for current and future diagnosis and treatment. The …

Increased incidence of candidemia in a tertiary care hospital with the COVID‐19 pandemic

M Nucci, G Barreiros, LF Guimarães… - Mycoses, 2021 - Wiley Online Library
Background The incidence of candidemia in our hospital has been stable over an 18‐year
period (1.3 episodes per 1000 admissions). Since March 2020, we have observed an …

The changing epidemiology of invasive fungal infections

DA Enoch, H Yang, SH Aliyu, C Micallef - Human fungal pathogen …, 2017 - Springer
Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis
and candidemia responsible for the majority of cases. This is predominantly driven by the …

Incidence, characteristics and outcome of ICU-acquired candidemia in India

A Chakrabarti, P Sood, SM Rudramurthy, S Chen… - Intensive care …, 2015 - Springer
Purpose A systematic epidemiological study on intensive care unit (ICU)-acquired
candidemia across India. Method A prospective, nationwide, multicentric, observational …

Invasive candidiasis in critical care: challenges and future directions

C Logan, I Martin-Loeches, T Bicanic - Intensive care medicine, 2020 - Springer
Invasive candidiasis is the most common critical care-associated fungal infection with a
crude mortality of~ 40–55%. Important factors contributing to risk of invasive candidiasis in …

Risk factors for candidemia: a prospective matched case-control study

J Poissy, L Damonti, A Bignon, N Khanna… - Critical care, 2020 - Springer
Background Candidemia is an opportunistic infection associated with high morbidity and
mortality in patients hospitalized both inside and outside intensive care units (ICUs) …

ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients

I Martin-Loeches, M Antonelli, M Cuenca-Estrella… - Intensive care …, 2019 - Springer
Introduction The term invasive candidiasis (IC) refers to both bloodstream and deep-seated
invasive infections, such as peritonitis, caused by Candida species. Several guidelines on …

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

A Rosenberg, IV Ene, M Bibi, S Zakin, ES Segal… - Nature …, 2018 - nature.com
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

Epidemiology and microbiologic characterization of nosocomial candidemia from a Brazilian national surveillance program

AM Doi, ACC Pignatari, MB Edmond, AR Marra… - PloS one, 2016 - journals.plos.org
Candidemia is a growing problem in hospitals all over the world. Despite advances in the
medical support of critically ill patients, candidiasis leads to prolonged hospitalization, and …