[HTML][HTML] Development and application of therapeutic antibodies against COVID-19

L Ning, HB Abagna, Q Jiang, S Liu… - International journal of …, 2021 - ncbi.nlm.nih.gov
The pandemic of Coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome 2 coronavirus (SARS-CoV-2) continues to be a global health crisis …

[HTML][HTML] Factors affecting the antibody immunogenicity of vaccines against SARS-CoV-2: A focused review

ZJ Cheng, M Xue, P Zheng, J Lyu, Z Zhan, H Hu… - Vaccines, 2021 - mdpi.com
Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects
of vaccines, as well as their common influencing factors, are the most important issues that …

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy …

WB Wang, Y Liang, YQ Jin, J Zhang, JG Su… - Journal of Molecular …, 2021 - Elsevier
The pandemic of the COVID-19 disease caused by SARS-CoV-2 has led to more than 200
million infections and over 4 million deaths worldwide. The progress in the developments of …

[HTML][HTML] Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies

E Laurini, D Marson, S Aulic, A Fermeglia, S Pricl - Scientific Reports, 2021 - nature.com
The purpose of this work is to provide an in silico molecular rationale of the role eventually
played by currently circulating mutations in the receptor binding domain of the SARS-CoV-2 …

In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein

Q Wang, F Meng, Y Xie, W Wang, Y Meng, L Li… - ACS central …, 2023 - ACS Publications
The spike protein of SARS-CoV-2 has been a promising target for developing vaccines and
therapeutics due to its crucial role in the viral entry process. Previously reported cryogenic …

[HTML][HTML] Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

OC Ubah, EW Lake, GS Gunaratne, JP Gallant… - Nature …, 2021 - nature.com
Abstract Single-domain Variable New Antigen Receptors (VNARs) from the immune system
of sharks are the smallest naturally occurring binding domains found in nature. Possessing …

[HTML][HTML] Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

S Halwe, A Kupke, K Vanshylla, F Liberta, H Gruell… - Viruses, 2021 - mdpi.com
Despite the recent availability of vaccines against severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2), there is an urgent need for specific anti-SARS-CoV-2 …

[HTML][HTML] RBD-specific antibody responses after two doses of BBIBP-CorV (Sinopharm, Beijing CNBG) vaccine

T Ferenci, B Sarkadi - BMC Infectious Diseases, 2022 - Springer
Background Limited information is available on the effectiveness of the BBIBP-CorV
(Sinopharm, Beijing CNBG) vaccine, especially in the elderly, despite the fact that it is …

Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin

R Otsubo, T Yasui - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody therapy is effective for treating infectious diseases. Due to the coronavirus disease
2019 (COVID-19) pandemic and the rise of drug-resistant bacteria, rapid development of …

[HTML][HTML] Multiple SARS-CoV-2 variants exhibit variable target cell infectivity and ability to evade antibody neutralization

H Tang, L Gao, Z Wu, F Meng, X Zhao, Y Shao… - Frontiers in …, 2022 - frontiersin.org
The continuous emergence of SARS-coronavirus 2 (SARS-CoV-2) variants, especially the
variants of concern (VOC), exacerbated the impact of the coronavirus disease 2019 (COVID …