Heat shock protein 60 (HSP60) and survivin reside in both the cytosolic and mitochondrial
compartments under physiological conditions. They can form HSP60-survivin complexes …

Background: Current therapeutic options for advanced pancreatic cancer have been largely
disappointing with modest results at best, and though adjuvant therapy remains …

Survivin, a member of the inhibitor of apoptosis protein family, is one of the most cancer-
specific proteins identified to date. Survivin expression is low or undetectable in most adult …

The expression of survivin, an inhibitor of apoptosis can be seen in most tumors and is
correlated with the angiogenic factor vascular endothelial growth factor (VEGF). But little is …

Head and neck squamous cell carcinoma (HNSCC) is a malignancy that is associated with
severe mortality despite advances in therapy. Today's standard treatment most commonly …

Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated
by chemoradiotherapy. However, the outcome has not improved significantly due to …

Here we demonstrated that sepantronium bromide (YM155), a survivin suppressant,
inhibited esophageal squamous-cell carcinoma (ESCC) growth in mice bearing human …

Based on their overexpression and important roles in progression and therapy-resistance in
malignant diseases, the inhibitor of apoptosis protein family (IAP) members, survivin and X …

Background Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis
evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of …

Survivin is expressed in the nucleus and/or cytoplasm of various malignant cells. Nuclear
survivin is critical for the completion of mitosis, while cytoplasmic survivin functions as an …