Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …
motor neurons. As with all major neurodegenerative disorders, development of disease …
Frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …
dementia and presents with early social–emotional–behavioural and/or language changes …
Longitudinal associations of blood phosphorylated Tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease
Importance Plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as
an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its …
an easily accessible biomarker for the detection of Alzheimer disease (AD) pathology, but its …
Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
Background Increasing evidence supports the use of plasma biomarkers of
neurodegeneration and neuroinflammation to screen and diagnose patients with dementia …
neurodegeneration and neuroinflammation to screen and diagnose patients with dementia …
Neurofilament light chain as a biomarker for cognitive decline in Parkinson disease
Background Neurofilament light chain protein (NfL) is a promising biomarker of
neurodegeneration. Objectives To determine whether plasma and CSF NfL (1) associate …
neurodegeneration. Objectives To determine whether plasma and CSF NfL (1) associate …
Neurofilament light chain as biomarker for amyotrophic lateral sclerosis and frontotemporal dementia
F Verde, M Otto, V Silani - Frontiers in neuroscience, 2021 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related
currently incurable neurodegenerative diseases. ALS is characterized by degeneration of …
currently incurable neurodegenerative diseases. ALS is characterized by degeneration of …
Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration
Objective To assess the diagnostic and prognostic value of serum neurofilament light (NfL)
and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal …
and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal …
Cerebrospinal fluid biomarkers of Alzheimer's disease: current evidence and future perspectives
DA McGrowder, F Miller, K Vaz, C Nwokocha… - Brain sciences, 2021 - mdpi.com
Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …
neurodegenerative disease characterized by a decline in cognition. Over the last two …
Plasma biomarkers for neurodegenerative disorders: ready for prime time?
Plasma biomarkers for neurodegenerative disorders: ready for... : Current Opinion in
Psychiatry Plasma biomarkers for neurodegenerative disorders: ready for prime time …
Psychiatry Plasma biomarkers for neurodegenerative disorders: ready for prime time …
Neurofilaments in motor neuron disorders: towards promising diagnostic and prognostic biomarkers
E Zucchi, V Bonetto, G Sorarù, I Martinelli… - Molecular …, 2020 - Springer
Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases.
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …