DEAD/H-box helicases: Anti-viral and pro-viral roles during infections

R Ullah, J Li, P Fang, S Xiao, L Fang - Virus Research, 2022 - Elsevier
Abstract DEAD/H-box RNA helicases make the prominent family of helicases super family-2
which take part in almost all RNA-related processes, from initiation of transcription to RNA …

Hepatitis C virus translation regulation

M Niepmann, GK Gerresheim - International journal of molecular sciences, 2020 - mdpi.com
Translation of the hepatitis C virus (HCV) RNA genome is regulated by the internal ribosome
entry site (IRES), located in the 5'-untranslated region (5′ UTR) and part of the core protein …

Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection

W McIntyre, R Netzband, G Bonenfant… - Nucleic Acids …, 2018 - academic.oup.com
More than 140 post-transcriptional modifications (PTMs) are known to decorate cellular
RNAs, but their incidence, identity and significance in viral RNA are still largely unknown …

DDX RNA helicases: key players in cellular homeostasis and innate antiviral immunity

I Tapescu, S Cherry - Journal of Virology, 2024 - journals.asm.org
ABSTRACT RNA helicases are integral in RNA metabolism, performing important roles in
cellular homeostasis and stress responses. In particular, the DExD/H-box (DDX) helicase …

[HTML][HTML] Cellular factors involved in the hepatitis C virus life cycle

HC Li, CH Yang, SY Lo - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
The hepatitis C virus (HCV), an obligatory intracellular pathogen, highly depends on its host
cells to propagate successfully. The HCV life cycle can be simply divided into several stages …

The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes

P Schult, K Paeschke - Biological chemistry, 2021 - degruyter.com
DHX36 is a member of the DExD/H box helicase family, which comprises a large number of
proteins involved in various cellular functions. Recently, the function of DHX36 in the …

RNA helicases as shadow modulators of cell cycle progression

O Sergeeva, T Zatsepin - International Journal of Molecular Sciences, 2021 - mdpi.com
The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-
dependent kinases. However, many proteins that control DNA replication, RNA transcription …

DEAD-box helicase DDX6 facilitated RIG-I-mediated type-I interferon response to EV71 infection

R Zhang, M Cheng, B Liu, M Yuan, D Chen… - Frontiers in Cellular …, 2021 - frontiersin.org
Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play
important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as …

RNA helicase DDX6 regulates A-to-I editing and neuronal differentiation in human cells

CY Shih, YC Chen, HY Lin, CY Chu - International Journal of Molecular …, 2023 - mdpi.com
The DEAD-box proteins, one family of RNA-binding proteins (RBPs), participate in post-
transcriptional regulation of gene expression with multiple aspects. Among them, DDX6 is …

Gene regulation in animal miRNA biogenesis

Z Liu, M Wang, A Cheng, X Ou, S Mao, Q Yang… - …, 2022 - Taylor & Francis
miRNAs are a class of noncoding RNAs of approximately 19–22 nucleotides that are widely
found in animals, plants, bacteria and even viruses. Dysregulation of the expression profile …