Domain III of the envelope protein as a dengue vaccine target
MG Guzman, L Hermida, L Bernardo… - Expert review of …, 2010 - Taylor & Francis
A dengue vaccine should induce long-lasting, simultaneous protection to the four dengue
viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …
viruses while avoiding the immune enhancement of viral infection. Domain III of the dengue …
Novel approaches to Neisseria meningitidis vaccine design
M Christodoulides, J Heckels - Pathogens and Disease, 2017 - academic.oup.com
A range of vaccines is available for preventing life-threatening diseases caused by infection
with Neisseria meningitidis (meningococcus, Men). Capsule polysaccharide (CPS) …
with Neisseria meningitidis (meningococcus, Men). Capsule polysaccharide (CPS) …
A recombinant fusion protein containing the domain III of the dengue-2 envelope protein is immunogenic and protective in nonhuman primates
L Hermida, L Bernardo, J Martín, M Alvarez, I Prado… - Vaccine, 2006 - Elsevier
We have previously reported the construction and evaluation in mice of recombinant fusion
proteins formed by a fragment (aa 286–426) of the dengue envelope protein and the P64k …
proteins formed by a fragment (aa 286–426) of the dengue envelope protein and the P64k …
Biotechnology in Cuba: 20 years of scientific, social and economic progress
EL Mola, R Silva, B Acevedo, JA Buxadó… - Journal of Commercial …, 2006 - Springer
An analysis of the biotechnology development in Cuba for 20 years has been attempted in
this paper. This paper deals with the evolution of the biotechnology sector from the 1980s …
this paper. This paper deals with the evolution of the biotechnology sector from the 1980s …
A dengue-2 Envelope fragment inserted within the structure of the P64k meningococcal protein carrier enables a functional immune response against the virus in mice
L Hermida, R Rodrı́guez, L Lazo, R Silva… - Journal of virological …, 2004 - Elsevier
A gene fragment encoding for the amino acids (aa) 286–426 from the dengue Envelope (E)
protein was expressed in Escherichia coli as two forms of fusion proteins. In one case, the E …
protein was expressed in Escherichia coli as two forms of fusion proteins. In one case, the E …
Immunological evaluation in nonhuman primates of formulations based on the chimeric protein P64k-domain III of dengue 2 and two components of Neisseria …
I Valdés, L Hermida, J Martín, T Menéndez, L Gil… - Vaccine, 2009 - Elsevier
The main problem in the development of successful vaccines against dengue based on
recombinant proteins is the necessity to use potent adjuvants to reach a proper functional …
recombinant proteins is the necessity to use potent adjuvants to reach a proper functional …
Amino acid changes in the recombinant Dengue 3 Envelope domain III determine its antigenicity and immunogenicity in mice
A Zulueta, J Martín, L Hermida, M Alvarez, I Valdés… - Virus research, 2006 - Elsevier
The immunogenicity of the Envelope fragment from amino acid 284 to 426 of Dengue
viruses, obtained as fusion proteins with P64k in Escherichia coli, has been previously …
viruses, obtained as fusion proteins with P64k in Escherichia coli, has been previously …
Effect of conjugation methodology on the immunogenicity and protective efficacy of meningococcal group C polysaccharide–P64k protein conjugates
T Carmenate, L Canaán, A Álvarez… - FEMS Immunology & …, 2004 - academic.oup.com
Neisseria meningitidis serogroup C polysaccharide (CCPS) was conjugated to the carrier
protein P64k using two different conjugation procedures, condensation mediated by …
protein P64k using two different conjugation procedures, condensation mediated by …
A fragment of the envelope protein from dengue‐1 virus, fused in two different sites of the meningococcal P64k protein carrier, induces a functional immune response …
L Hermida, R Rodríguez, L Lazo… - Biotechnology and …, 2004 - Wiley Online Library
Previously we have reported the capacity of the fusion protein PD3, composed of the P64k
protein and the envelope (E) fragment from amino acids (aa) 286–426 of dengue‐2 virus …
protein and the envelope (E) fragment from amino acids (aa) 286–426 of dengue‐2 virus …
Evaluation in mice of the immunogenicity and protective efficacy of a tetravalent subunit vaccine candidate against dengue virus
L Lazo, A Izquierdo, E Suzarte, L Gil… - Microbiology and …, 2014 - Wiley Online Library
ABSTRACT A dengue vaccine must induce protective immunity against the four serotypes of
the virus. Our group has developed chimeric proteins consisting of the protein P64k from …
the virus. Our group has developed chimeric proteins consisting of the protein P64k from …