Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …

Bone formation or regeneration requires the recruitment, proliferation, and osteogenic
differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is …

The fatal determination of bone marrow mesenchymal stem/stromal cells (BMSC) is closely
associated with mechano-environmental factors in addition to biochemical clues. The aim of …

Biomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory
outcomes. Here, it is investigated how human bone‐marrow‐derived mesenchymal stem …

In bone tissue engineering, prediction of forces induced to the native bone during normal
functioning is important in the design, fabrication, and integration of a scaffold with the host …

The repair of critical bone defects remains challenging worldwide. Three canonical pillars
(biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have …

Mesenchymal stem cells (MSCs) can sense and convert mechanical stimuli signals into a
chemical response. Integrins are involved in the mechanotransduction from inside to outside …