Neutrophil extracellular traps (NETs) have recently emerged as a newly recognized
contributor to venous and arterial thrombosis. These strands of DNA extruded by activated or …

The activating interplay of thrombosis and inflammation (thromboinflammation) has been
established as a major underlying pathway, driving not only cardiovascular disease but also …

Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain
containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of …

Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Objective: Whether endotheliopathy only mirrors coronavirus disease 2019 (COVID-19)
severity or plays an intrinsic role in microvascular thrombosis and organ failure remains …

Neutrophils play a central role in innate immune defense. Advances in neutrophil biology
have brought to light the capacity of neutrophils to release their decondensed chromatin and …

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an
important element that propels the pathological progression of a plethora of diseases. DNA …

Background: Peptidyl arginine deiminase 4 (PAD4) is an enzyme that converts arginine into
citrulline. PAD4 is expressed in neutrophils that, when activated, can drive the formation of …

Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for
thrombosis and inflammation. During these processes, a complex series of events, including …

Arterial and venous thrombosis constitute a major source of morbidity and mortality
worldwide. Association between thrombotic complications and cardiovascular and other …