Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Intervertebral disc degeneration (IDD) is a common cause of joint-related chronic disability
in elderly individuals worldwide. It seriously impacts the quality of life and inflicts a …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Aging is a major risk factor for chronic diseases and disability in humans. Nowadays, no
effective anti-aging treatment is available clinically. In this study, oridonin was selected …

The relationship between transcription and aging is one that has been studied intensively
and experimentally with diverse attempts. However, the impact of the nuclear mRNA export …

During an organism's lifespan, two main phenomena are critical for the organism's survival.
These are (1) a proper embryonic development, which permits the new organism to function …

Aging is a complex biological process characterized by the gradual decline of cellular
functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia …

Loss of transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3) contributes to
shorter lifespans in eukaryotes. However, the molecular mechanism of the decline of …