Chronic lymphocytic leukemia
N Chiorazzi, KR Rai, M Ferrarini - New England Journal of …, 2005 - Mass Medical Soc
Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone
remarkable changes during the past decade. This review addresses the latest ideas …
remarkable changes during the past decade. This review addresses the latest ideas …
The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: insight into disease biology and new targeted therapies
JA Burger, JG Gribben - Seminars in cancer biology, 2014 - Elsevier
Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1
A subset of blood cells from patients with B-cell chronic lymphocytic leukemia (CLL)
spontaneously differentiates in vitro into large, round, or fibroblast-like adherent cells that …
spontaneously differentiates in vitro into large, round, or fibroblast-like adherent cells that …
Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance
Leukemia cells are protected from chemotherapy-induced apoptosis by their interactions
with bone marrow mesenchymal stromal cells (BM-MSCs). Yet the underlying mechanisms …
with bone marrow mesenchymal stromal cells (BM-MSCs). Yet the underlying mechanisms …
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
L Granziero, P Ghia, P Circosta… - Blood, The Journal …, 2001 - ashpublications.org
In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
Z Zeng, Y Xi Shi, IJ Samudio, RY Wang… - Blood, The Journal …, 2009 - ashpublications.org
Abstract SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow
microenvironment interactions. We previously reported that bone marrow–derived stromal …
microenvironment interactions. We previously reported that bone marrow–derived stromal …
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
Chemokines play a central role for lymphocyte trafficking and homing. The mechanisms that
direct the tissue localization of B cells from patients with chronic lymphocytic leukemia (B …
direct the tissue localization of B cells from patients with chronic lymphocytic leukemia (B …
[HTML][HTML] G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent
LJ Bendall, KF Bradstock - Cytokine & growth factor reviews, 2014 - Elsevier
G-CSF was among the first cytokines to be identified and rapidly transitioned into clinical
medicine. Initially used to promote the production of neutrophils in patients with …
medicine. Initially used to promote the production of neutrophils in patients with …
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal …
AV Kurtova, K Balakrishnan, R Chen… - Blood, The Journal …, 2009 - ashpublications.org
Marrow stromal cells (MSCs) provide important survival and drug resistance signals to
chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL–MSC …
chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL–MSC …
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
M Konopleva, S Konoplev, W Hu, AY Zaritskey… - Leukemia, 2002 - nature.com
The aim of this study was to study interactions between stromal bone marrow
microenvironment and leukemic cells. We tested the hypothesis that stromal cells prevent …
microenvironment and leukemic cells. We tested the hypothesis that stromal cells prevent …