Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …

Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Because of their rare detection in atherosclerotic lesions, the involvement of neutrophils in
the pathophysiology of atherosclerosis has been largely denied. However, over the past …

The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in
inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and …

The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a
role in tumor development. However, CXCR2 influences tumors through multiple …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

Atherosclerosis is a progressive disorder of the arterial wall and the underlying cause of
cardiovascular diseases such as heart attack and stroke. Today, atherosclerosis is …

The fundamental importance of chemokines for atherogenesis, progression, and
destabilization of atherosclerotic plaques is now widely appreciated, but the degree of …