Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural
scaffold and the catalytic center of protein synthesis in every living organism. In eukaryotes …

Ribosomes are essential macromolecular machines responsible for translating the genetic
information encoded in mRNAs into proteins. Ribosomes are composed of ribosomal RNAs …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …

Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle
arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to …

Dysregulated transcription due to disruption in histone lysine methylation dynamics is an
established contributor to tumorigenesis,. However, whether analogous pathologic …

Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual
disability. The exact pathophysiological mechanism underlying MCPH remains to be …

RNA-binding proteins (RBPs) play key roles in a wide range of physiological and
pathological processes. To facilitate the investigation of RBP functions and disease …

The spatial organization of molecules in a cell is essential for their functions. While current
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …

To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells
have established mechanisms to regulate selective mRNA export through the nuclear pore …

The prevalence of aged people has increased rapidly in recent years and brings profound
demographic changes worldwide. The multi-level progression of aging occurs at diverse …