Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

The renin-angiotensin system is of vital significance not only in the maintenance of blood
pressure but also because of its role in the pathophysiology of different organ systems in the …

Uteroplacental blood flow increases as pregnancy advances. Adequate supply of nutrients
and oxygen carried by uteroplacental blood flow is essential for the well-being of the mother …

Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the
bidirectional maternal–fetal exchanges of respiratory gases and to provide sole nutrient …

Transplantation (Tx) remains the optimal therapy for end-stage disease (ESD) of various
solid organs. Although alloimmune events remain the leading cause of long-term allograft …

Cardiovascular diseases (CVDs) characterized by sex–gender differences remain a leading
cause of death globally. Hence, it is imperative to understand the underlying mechanisms of …

During pregnancy, the maternal cardiovascular system undergoes significant changes,
including increased heart rate, cardiac output, plasma volume, and uteroplacental blood …

Fetal growth throughout pregnancy relies on delivery of an increasing volume of maternal
blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and …

Elevated endogenous estrogens stimulate human uterine artery endothelial cell (hUAEC)
hydrogen sulfide (H 2 S) production by selectively upregulating the expression of H 2 S …

Endogenous hydrogen sulfide (H2S) produced by cystathionine β-synthase (CBS) and
cystathionine-γ lyase (CSE) has emerged as a novel uterine vasodilator contributing to …