Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Since the disclosure of adult mesenchymal stem cells (MSCs), there have been an intense
investigation on the characteristics of these cells and their potentialities. Dental stem cells …

Human endothelial cells (ECs) and pericytes are of great interest for research on vascular
development and disease, as well as for future therapy. This protocol describes the efficient …

Objective—Endothelial cells (ECs), pericytes, and vascular smooth muscle cells (vSMCs)
are essential for vascular development, and their dysfunction causes multiple cardiovascular …

Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by weak
blood vessels. HHT1 is caused by mutations in the ENDOGLIN (ENG) gene. Here, we …

Precise genome editing involves homologous recombination between donor DNA and
chromosomal sequences subjected to double-stranded DNA breaks made by …

Induced pluripotent stem cells (iPSCs) have entered an unprecedented state of
development since they were first generated. They have played a critical role in disease …

Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage
cells is considered a realistic option for cartilage regeneration. We explored whether human …

It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured
cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from …

Pompe disease is a metabolic myopathy caused by deficiency of the acid α-glucosidase
(GAA) enzyme and results in progressive wasting of skeletal muscle cells. The c.-32-13T> G …