Immune dysregulation is a cardinal feature of chronic lymphocytic leukemia (CLL) from its
early stage and worsens during clinical observation, even in absence of disease …

Signal transducers and activators of transcription (STATs) are cytoplasmic transcription
factors that have a key role in cell fate. STATs, a protein family comprised of seven members …

B lymphocytes are the effectors of humoral immunity, providing defense against pathogens
through different functions including antibody production. B cells constitute approximately …

Regulatory B cells (Bregs) may act earlier than regulatory T cells (Tregs) and may play as
important a role in autoimmune and allergic diseases. Obstacles to the investigation of …

CD5 is a pan-T-cell surface marker and is rarely expressed in diffuse large B-cell lymphoma
(DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking in Western countries. In …

Results Patients with active ANCA-SVV had lower% CD5+ B cells, whereas% CD5+ B cells
from patients in remission were indistinguishable from healthy controls. After rituximab …

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of small
mature-looking CD19+ CD23+ CD5+ B-cells that accumulate in the blood, bone marrow …

Systemic lupus erythematosus (SLE) disease is an autoimmune disease of unknown
aetiology that affects predominantly women of child bearing age. Since previous studies …

B lymphocytes are critical for effective immunity; they produce antibodies and cytokines,
present antigens to T lymphocytes and regulate immune responses. However, because of …

Ibrutinib (BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to
a large extent, does not cause cell death directly and does not eradicate CLL malignant …