BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-
omics approaches could lead to the identification of novel molecular targets. Here, we …

Valvular heart disease is a common cause of morbidity and mortality worldwide and has no
effective medical therapy. Severe disease is managed with valve replacement procedures …

Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …

These new insights into the genetic contributors of AVD have offered new avenues for
translational disease investigation, bridging molecular discoveries to emergent …

Importance Nonsyndromic bicuspid aortic valve (nsBAV) is the most common congenital
heart valve malformation. BAV has a heritable component, yet only a few causative genes …

Turner syndrome (TS) is a chromosomal disorder caused by complete or partial loss of the
second sex chromosome and exhibits phenotypic heterogeneity, even after accounting for …

Despite devastating clinical sequelae of calcific aortic valve disease that range from left
ventricular remodeling to arrhythmias, heart failure, and early death, the molecular insights …

Importance Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist.
However, it is unknown which genetic and cardiovascular risk factors might be AS-specific …