Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

The cellular processes underpinning life are orchestrated by proteins and their interactions.
The associated structural and dynamic heterogeneity, despite being key to function, poses a …

Membrane proteins play critical biochemical roles but remain challenging to study. Recently,
native or nondenaturing mass spectrometry (MS) has made great strides in characterizing …

Historically, the main barrier to membrane protein investigations has been the tendency of
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …

Integral membrane proteins (IMPs) are biologically highly significant but challenging to study
because they require maintaining a cellular lipid-like environment. Here, we explore the …

Nowadays, there has been an increasing utilization of nanomedicines for disease treatment.
Nanodiscs (NDs) have emerged as a novel platform technology that garners significant …

Nanodiscs provide an excellent system for the structure-function investigation of membrane
proteins. Its direct advantage lies in presenting a water-soluble form of an otherwise …

Receptor tyrosine kinases of the human epidermal growth factor receptor (HER or ErbB)
family transduce biochemical signals across plasma membrane, playing a significant role in …

The choice of a suitable membrane mimicking environment is of fundamental importance for
the characterization of structure and function of membrane proteins. In this respect, usage of …