Human endogenous retroviruses are ancient acquired elements still shaping innate immune responses

N Grandi, E Tramontano - Frontiers in immunology, 2018 - frontiersin.org
About 8% of our genome is composed of sequences with viral origin, namely human
Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the …

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation

C Lavialle, G Cornelis, A Dupressoir… - … of the Royal …, 2013 - royalsocietypublishing.org
The development of the emerging field of 'paleovirology'allows biologists to reconstruct the
evolutionary history of fossil endogenous retroviral sequences integrated within the genome …

HERV envelope proteins: physiological role and pathogenic potential in cancer and autoimmunity

N Grandi, E Tramontano - Frontiers in microbiology, 2018 - frontiersin.org
Human endogenous retroviruses (HERVs) are relics of ancient infections accounting for
about the 8% of our genome. Despite their persistence in human DNA led to the …

The multifaceted role of GCM1 during trophoblast differentiation in the human placenta

MJ Jeyarajah, G Jaju Bhattad… - Proceedings of the …, 2022 - National Acad Sciences
Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a
critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical …

From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation

A Dupressoir, C Lavialle, T Heidmann - Placenta, 2012 - Elsevier
During their replication, infectious retroviruses insert a reverse-transcribed cDNA copy of
their genome, a “provirus”, into the genome of their host. If the infected cell belongs to the …

Control of human trophoblast function

L Lunghi, ME Ferretti, S Medici, C Biondi… - Reproductive Biology and …, 2007 - Springer
The trophoblast, ie the peripheral part of the human conceptus, exerts a crucial role in
implantation and placentation. Both processes properly occur as a consequence of an …

The evolution, regulation, and function of placenta-specific genes

SM Rawn, JC Cross - Annual review of cell and developmental …, 2008 - annualreviews.org
A number of placenta-specific genes (eg, Tpbp, Plac1, Syncytin, and retrotransposon-
associated genes such as Peg10, Rtl1, Endothelin B receptor, Insl4, Leptin, Midline1, and …

Human RNA “rumor” viruses: the search for novel human retroviruses in chronic disease

C Voisset, RA Weiss, DJ Griffiths - Microbiology and Molecular …, 2008 - Am Soc Microbiol
Retroviruses are an important group of pathogens that cause a variety of diseases in
humans and animals. Four human retroviruses are currently known, including human …

Cell-cell fusion mediated by viruses and HERV-derived fusogens in cancer initiation and progression

T Dittmar, J Weiler, T Luo, R Hass - Cancers, 2021 - mdpi.com
Simple Summary Even though it is known that (cancer) cells can fuse, it is still less
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …

Transactivation of elements in the human endogenous retrovirus W family by viral infection

C Nellåker, Y Yao, L Jones-Brando, F Mallet… - Retrovirology, 2006 - Springer
Background Aberrant expression of human endogenous retrovirus (HERV) elements in the
W family has previously been associated with schizophrenia, multiple sclerosis and …