[HTML][HTML] A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology
R Eckenstaler, M Hauke, RA Benndorf - Biochemical Pharmacology, 2022 - Elsevier
The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …
of signal transduction in a variety of cellular processes, including regulation of actomyosin …
Conformational regulation of AP1 and AP2 clathrin adaptor complexes
GM Beacham, EA Partlow, G Hollopeter - Traffic, 2019 - Wiley Online Library
Heterotetrameric clathrin adaptor protein complexes (APs) orchestrate the formation of
coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes …
coated vesicles for transport among organelles of the cell periphery. AP1 binds membranes …
Structure of an inactive conformation of GTP-bound RhoA GTPase
Y Lin, S Lu, J Zhang, Y Zheng - Structure, 2021 - cell.com
By using 31 P NMR, we present evidence that the Rho family GTPase RhoA, similar to Ras
GTPases, exists in an equilibrium of conformations when bound to GTP. High-resolution …
GTPases, exists in an equilibrium of conformations when bound to GTP. High-resolution …
Implications of farnesyltransferase and its inhibitors as a promising strategy for cancer therapy
SG Klochkov, ME Neganova, NS Yarla… - Seminars in cancer …, 2019 - Elsevier
Ras proteins have been reported to play key role in oncologic diseases. Ras proteins are
associated with cellular membranes for its carcinogenic activities through post-translational …
associated with cellular membranes for its carcinogenic activities through post-translational …
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding
Rac1 is a small member of the Rho GTPase family. One of the most important downstream
effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational …
effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational …
In silico identification and characterization of small-molecule inhibitors specific to RhoG/Rac1 signaling pathway
Rho family GTPases serve as molecular switches in numerous cellular processes, and their
overexpression is involved in disease conditions. RhoG is one of the less explored Rho …
overexpression is involved in disease conditions. RhoG is one of the less explored Rho …
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer
Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of
Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role …
Rho guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role …
Common mechanism of activated catalysis in P-loop fold nucleoside triphosphatases—United in diversity
MI Kozlova, DN Shalaeva, DV Dibrova… - Biomolecules, 2022 - mdpi.com
To clarify the obscure hydrolysis mechanism of ubiquitous P-loop-fold nucleoside
triphosphatases (Walker NTPases), we analysed the structures of 3136 catalytic sites with …
triphosphatases (Walker NTPases), we analysed the structures of 3136 catalytic sites with …
Leveraging Bidirectional Nature of Allostery To Inhibit Protein–Protein Interactions (PPIs): A Case Study of PCSK9–LDLR Interaction
The protein PCSK9 (proprotein convertase subtilisin/Kexin type 9) negatively regulates the
recycling of LDLR (low-density lipoprotein receptor), leading to an elevated plasma level of …
recycling of LDLR (low-density lipoprotein receptor), leading to an elevated plasma level of …
Role of Calcium in Modulating the Conformational Landscape and Peptide Binding Induced Closing of Calmodulin
Metal ions play an essential role in several cellular functions. Calcium is a ubiquitous
regulator and is involved in numerous physiological processes. A class of proteins have …
regulator and is involved in numerous physiological processes. A class of proteins have …