Multi-omics profiling for health

M Babu, M Snyder - Molecular & Cellular Proteomics, 2023 - ASBMB
The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

Microbiome epidemiology and association studies in human health

H VanEvery, EA Franzosa, LH Nguyen… - Nature Reviews …, 2023 - nature.com
Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review

CR Bain, PS Myles, T Corcoran, JM Dieleman - Anaesthesia, 2023 - Wiley Online Library
In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …

SingPro: a knowledge base providing single-cell proteomic data

X Lian, Y Zhang, Y Zhou, X Sun, S Huang… - Nucleic Acids …, 2024 - academic.oup.com
Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …

Discovery of sparse, reliable omic biomarkers with Stabl

J Hédou, I Marić, G Bellan, J Einhaus… - Nature …, 2024 - nature.com
Adoption of high-content omic technologies in clinical studies, coupled with computational
methods, has yielded an abundance of candidate biomarkers. However, translating such …

Cooperative learning for multiview analysis

DY Ding, S Li, B Narasimhan… - Proceedings of the …, 2022 - National Acad Sciences
We propose a method for supervised learning with multiple sets of features (“views”). The
multiview problem is especially important in biology and medicine, where “-omics” data …

Difficulties in adaptation of the mother and newborn via cesarean section versus natural birth—A narrative review

VV Lupu, IC Miron, AA Raileanu, IM Starcea, A Lupu… - Life, 2023 - mdpi.com
Birth is a physiological act that is part of the morpho-functional economy of the maternal
body. Each stage in the act of birth has a predetermined pathway that is neurohormonally …

[HTML][HTML] A single-cell atlas of the myometrium in human parturition

R Pique-Regi, R Romero, V Garcia-Flores… - JCI insight, 2022 - ncbi.nlm.nih.gov
Parturition is a well-orchestrated process characterized by increased uterine contractility,
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …

Abrupt perturbation and delayed recovery of the vaginal ecosystem following childbirth

EK Costello, DB DiGiulio, A Robaczewska… - Nature …, 2023 - nature.com
The vaginal ecosystem is closely tied to human health and reproductive outcomes, yet its
dynamics in the wake of childbirth remain poorly characterized. Here, we profile the vaginal …

Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low-and middle-income countries

CA Espinosa, W Khan, R Khanam, S Das, J Khalid… - Science …, 2023 - science.org
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive
studies are hindered by its multiple complex etiologies. Epidemiological associations …