The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Assessments of safety and efficacy are crucial before human ESC (hESC) therapies can
move into the clinic. Two important early potential hESC applications are the use of retinal …

Transformation of somatic cells with a set of embryonic transcription factors produces cells
with the pluripotent properties of embryonic stem cells (ESCs). These induced pluripotent …

Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of
photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

Purpose.: To evaluate cell survival and tumorigenicity of human embryonic stem cell–
derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised …

Slow horizontal head and body rotation occurs in mice and rats when the visual field is
rotated around them, and these optomotor movements can be produced reliably in a virtual …

Human stem-cell derivatives are likely to play an important role in the future of regenerative
medicine. Evaluation and comparison to their in vivo counterparts is critical for assessment …

The retinal pigment epithelium (RPE) is a monolayer of cells underlying and supporting the
neural retina. It begins as a plastic tissue, capable, in some species, of generating lens and …