The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to
facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of …

Myoblast fusion is a critical process that contributes to the growth of muscle during
development and to the regeneration of myofibers upon injury. Myoblasts fuse with each …

Highlights•Tension in cell membrane is produced by actin-membrane interactions, osmotic
and adhesion forces.•As other membrane reshaping processes, membrane fusion depends …

Cell patterning is typically accomplished by selectively depositing proteins for cell adhesion
only on patterned regions; however in tissues, cells are also influenced by mechanical …

Rho GTPase activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that
converts the small G proteins RhoA and Cdc42 to their inactive GDP-bound forms. It is …

Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel …

Serological testing for anti-neural autoantibodies is important in patients presenting with
idiopathic cerebellar ataxia, since these autoantibodies may indicate cancer, determine …

Myoblast fusion into multinucleated myotubes is a crucial step in skeletal muscle
development and regeneration. Here, we accumulated murine myoblasts at the ready-to …