The neural circuits governing vital behaviors, such as respiration and locomotion, are
comprised of discrete neuronal populations residing within the brainstem and spinal cord …

Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila
melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) …

The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules,, interacts with distinct molecules …

Hox genes encode a family of transcriptional regulators that elicit distinct developmental
programmes along the head-to-tail axis of animals. The specific regional functions of …

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

Collinear regulation of Hox genes in space and time has been an outstanding question ever
since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

Thousands of proteins localize to the nucleus; however, it remains unclear which contain
transcriptional effectors. Here, we develop HT-recruit, a pooled assay where protein libraries …

Although all bilaterian animals have a related set of Hox genes, the genomic organization of
this gene complement comes in different flavors. In some unrelated species, Hox genes are …

Head development in vertebrates involves a complex series of molecular and
morphogenetic events that generate a coordinated pattern of cartilages, bones and nerves …