Pupil dilation is mediated by a sympathetic output acting in opposition to
parasympathetically mediated pupil constriction. While light stimulates the parasympathetic …

Therapy-related augmentation of the symptoms of restless legs syndrome (RLS) is an
important clinical problem reported in up to 60% of patients treated with levodopa and, to a …

A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is
suggested by evidence that manipulations of DA receptors can alter the expression of some …

Previous work from our laboratory indicated that female Wistar rats will self-administer
ethanol (EtOH) directly into the posterior ventral tegmental area (VTA). These results …

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders,
and in many disease states, dopamine receptor number is altered. Here we identify a …

Dysbindin has been implicated in the pathogenesis of schizophrenia, but little is known
about how dysbindin affects neuronal function in the circuitry underlying psychosis and …

The meso-limbic dopamine (DA) system has an important role in regulating alcohol drinking.
Previous findings from our laboratory indicated that Wistar rats self-administered ethanol …

Mutations in LRRK2 play a critical role in both familial and sporadic Parkinson's disease
(PD). Up to date, the role of LRRK2 in PD onset and progression remains largely unknown …

Corticosteroids (CORT) have been widely used in anti-inflammatory medication. Chronic
CORT treatment can cause mesocorticolimbic system dysfunctions, which are known to play …

Abnormalities in NMDA receptor (NMDAR) function have been implicated in schizophrenia.
Here, we show that dysbindin, a schizophrenia-susceptibility gene widely expressed in the …