Cisplatin, an inorganic complex of platinum, is a chemotherapeutic drug that has been used
for 45 years. Despite the progress of pharmaceutical sciences and medicine and the …

Bilirubin (BR) is among the most potent endogenous antioxidants that originates from the
heme catabolic pathway. Despite being considered as a dangerous and cytotoxic waste …

Cisplatin is a widely-used chemotherapeutic agent for the treatment of various solid
neoplasms including colon cancer. Cisplatin-induced DNA damage is restricted due to dose …

Carbon nanostructures are considered distinctive multi-functional drug delivery platforms for
cancer therapy. However, their potential biocompatibility is still a significant challenge and …

RNA interference (RNAi) is a well-known post-transcriptional gene-silencing mechanism
that has garnered significant attention as a potentially powerful therapeutic procedure for …

Despite the investment in platinum drugs research, cisplatin, carboplatin and oxaliplatin are
still the only Pt-based compounds used as first line treatments for several cancers, with a few …

Current challenges in oncology are largely associated with the need to improve the
effectiveness of cancer treatment and to reduce drug's side effects. An effective strategy to …

In this study, we have developed a redox-sensitive (RS) liposomal doxorubicin formulation
by incorporating 10, 10′-diselanediylbis decanoic acid (DDA) organoselenium compound …

Chemotherapy, a conventional breast cancer treatment, has limitations due to its non-
specific mechanisms and undesirable side effects. Lipid-based nanoparticles (LNPs) have …

Colorectal cancer (CC) is the third most common and aggressive cancer reported. Globally
the affected ones may develop with high mortality rate even after the anticancer therapy …