Endothelial activation and inflammation are important mediators of accelerated
atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep …

SUMMARY 1 Cerebral vessels express oestrogen receptors (ER) in both the smooth muscle
and endothelial cell layers of cerebral blood vessels. Levels of ERα are higher in female rats …

Cyclooxygenase (COX) is the rate-limiting enzyme in the metabolism of arachidonic acid
into prostanoids. Although it is constitutively expressed in brain neurons, the inducible …

Cyclooxygenase (COX)-2 is expressed in the heart in animal models of ischemic injury.
Recent studies have suggested that COX-2 products are involved in inflammatory cell …

Interleukin (IL)-1β is a potent inducer of inflammatory prostaglandins, which are important
mediators of vascular response to cerebral injury, whereas estrogen reduces brain injury in …

In this review, we summarize the role of hyperglycemia during cerebral ischemia.
Hyperglycemia occurring during experimental and clinical stroke has been associated with …

Increased spinal cyclooxygenase activity is associated with nociception induced by tissue
inflammation. In the present study, we examined the changes of cyclooxygenase-1 and …

The underlying factors promoting increased mitochondrial proteins, mtDNA, and dilation to
mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal …

Background and Purpose—Production of NO by endothelial NO synthase (eNOS) plays a
protective role in cerebral ischemia. We studied the effects of transient focal ischemia on …

Long noncoding RNAs (lncRNAs) have emerged as critical regulators in numerous
biological processes. The arachidonic acid (AA) metabolic pathway is a fundamental …