Neuroimaging based biotypes for precision diagnosis and prognosis in cancer-related cognitive impairment

SR Kesler, AM Henneghan, S Prinsloo, O Palesh… - Frontiers in …, 2023 - frontiersin.org
Cancer related cognitive impairment (CRCI) is commonly associated with cancer and its
treatments, yet the present binary diagnostic approach fails to capture the full spectrum of …

Current evidence supporting associations of DNA methylation measurements with survivorship burdens in cancer survivors: A scoping review

M Sayer, DQ Ng, R Chan, K Kober, A Chan - Cancer Medicine, 2024 - Wiley Online Library
Introduction Identifying reliable biomarkers that reflect cancer survivorship symptoms
remains a challenge for researchers. DNA methylation (DNAm) measurements reflecting …

Senolytic treatment alleviates doxorubicin‐induced chemobrain

V Budamagunta, A Kumar, A Rani… - Aging cell, 2024 - Wiley Online Library
Doxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced
cognitive impairments (chemobrain). Chemobrain is associated with inflammation and …

Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients

DQ Ng, I Cheng, C Wang, CJ Tan, YL Toh, YQ Koh… - Scientific Reports, 2023 - nature.com
Brain-derived neurotrophic factor (BDNF) improves cognitive function by stimulating
neurogenesis and neuroplasticity. We hypothesize that higher plasma BDNF levels are …

[HTML][HTML] The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype

T Demby, PS Gross, J Mandelblatt, JK Huang… - Experimental …, 2024 - Elsevier
Many cancer patients experience serious cognitive problems related to their treatment,
which can greatly affect their quality of life. The molecular mechanisms of this cancer …

[HTML][HTML] Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

S Zhu, J Shi, Q Jin, Y Zhang, R Zhang, X Chen… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
The frequently repeated administration of alprazolam (Alp), a highly effective
benzodiazepine sedative-hypnotic agent, in anxiety, insomnia, and other diseases is closely …

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences

SM El-Khatib, AR Vagadia, ACD Le, JE Baulch… - Acta Neuropathologica …, 2024 - Springer
Cranial radiation therapy (RT) for brain cancers is often associated with the development of
radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life …

[HTML][HTML] Synergistic effects of aerobic exercise and transcranial direct current stimulation on executive function and biomarkers in healthy young adults

Y Ji, X Ni, K Zheng, Y Jiang, C Ren, H Zhu, M Xiao… - Brain Research …, 2023 - Elsevier
Objective This research explored the combined effects of transcranial direct current
stimulation (tDCS) and aerobic exercise (AE) on executive function and specific serum …

Doxorubicin impairs cognitive function by upregulating AMPAR and NMDAR subunit expression and increasing neuroinflammation, oxidative stress, and apoptosis in …

AH Alhowail, MA Aldubayan - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: The anticancer drug doxorubicin (DOX) is used for various malignancies.
However, it also causes cognitive impairment in cancer survivors. In order to determine the …

Genetic-epigenetic-neuropeptide associations in mood and anxiety disorders: Toward personalized medicine

M Gilani, N Abak, M Saberian - Pharmacology Biochemistry and Behavior, 2024 - Elsevier
Mood and anxiety disorders are complex psychiatric conditions shaped by the multifactorial
interplay of genetic, epigenetic, and neuropeptide factors. This review aims to elucidate the …