Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies

P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics

P Soininen, AJ Kangas, P Würtz, T Suna… - Circulation …, 2015 - Am Heart Assoc
Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …

[HTML][HTML] Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

P Sen, S Qadri, PK Luukkonen, O Ragnarsdottir… - Journal of …, 2022 - Elsevier
Background & aims Recent experimental models and epidemiological studies suggest that
specific environmental contaminants (ECs) contribute to the initiation and pathology of non …

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts

P Würtz, AS Havulinna, P Soininen, T Tynkkynen… - Circulation, 2015 - Am Heart Assoc
Background—High-throughput profiling of circulating metabolites may improve
cardiovascular risk prediction over established risk factors. Methods and Results—We …

Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

[HTML][HTML] High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies

HB Beyene, G Olshansky, AA T. Smith, C Giles… - PLoS …, 2020 - journals.plos.org
Obesity and related metabolic diseases show clear sex-related differences. The growing
burden of these diseases calls for better understanding of the age-and sex-related metabolic …

Biomarker profiles in heart failure patients with preserved and reduced ejection fraction

J Tromp, MAF Khan, IJT Klip, S Meyer… - Journal of the …, 2017 - Am Heart Assoc
Background Biomarkers may help us to unravel differences in the underlying
pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HF r …

Metabolic predictors of incident coronary heart disease in women

NP Paynter, R Balasubramanian, F Giulianini… - Circulation, 2018 - Am Heart Assoc
Background: Although metabolomic profiling offers promise for the prediction of coronary
heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in …

[HTML][HTML] Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

P Würtz, Q Wang, AJ Kangas, RC Richmond… - PLoS …, 2014 - journals.plos.org
Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We
aimed to determine to what extent elevated body mass index (BMI) within the normal weight …

The metabolomics of human aging: Advances, challenges, and opportunities

DJ Panyard, B Yu, MP Snyder - Science Advances, 2022 - science.org
As the global population becomes older, understanding the impact of aging on health and
disease becomes paramount. Recent advancements in multiomic technology have allowed …