Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …

Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …

The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …

Mitochondrial cytochrome c oxidase (COX) is the primary site of cellular oxygen
consumption and is essential for aerobic energy generation in the form of ATP. Human COX …

Mitochondrial cytochrome c oxidase (CcO) or respiratory chain complex IV is a heme aa 3-
copper oxygen reductase containing metal centers essential for holo-complex biogenesis …

Copper is required for the activity of cytochrome c oxidase (COX), the terminal electron-
accepting complex of the mitochondrial respiratory chain. The likely source of copper used …

Mitochondrial respiration is an energy producing process that involves the coordinated
action of several protein complexes embedded in the inner membrane to finally produce …

In eukaryotic cells, mitochondria perform cellular respiration through a series of redox
reactions ultimately reducing molecular oxygen to water. The system responsible for this …