Proteinase-binding a-macroglobulins (DIMS)'are large glycoproteins found in the circulation
of vertebrates and invertebrates, and in bird and reptile egg whites. aMs function as …

Hepatic acute phase response is defined as the metabolic reaction of the liver to systemic
tissue injury (93). The most prominent change is seen in the pattern of plasma proteins …

A KEY step in the elimination of pathogens from the body is the covalent binding of
complement proteins C3 and C4 to their surfaces1–5. Proteolytic activation of these proteins …

The amino acid sequence of a 90-residue segment of human pregnancy zone protein
containing its bait region has been determined. Human α 2-macroglobulin, human …

Our laboratory has previously characterized and purified the hyaluronan receptor by
hyaluronan affinity chromatography of rat liver endothelial cells. We have now isolated the …

The interaction between human fibroblast collagenase and five mammalian a-
macroglobulins (human α 2-macroglobulin and pregnancy zone protein, rat α 1-and α 2 …

Transcuprein is a high-affinity copper carrier in the plasma that is involved in the initial
distribution of copper entering the blood from the digestive tract. To identify and obtain cDNA …

In the course of a large scale analysis of late-expressed genes in the human epidermis, we
identified a new member of the α 2-macroglobulin (α2M) protease inhibitor family, A2ML1 …

The inhibitory capacity of the α-macroglobulins resides in their ability to entrap proteinase
molecules and thereby hinder the access of high molecular weight substrates to the …

Revised Manuscript Received June 11, 1990 abstract: Significant primary sequence
homology between the a-macroglobulin family of proteinase inhibitors and the complement …