The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …

The past 7 years have witnessed remarkable progress in our understanding of the genetics
of BCR-ABL–negative myeloproliferative neoplasms (MPNs) and has revealed layers of …

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are
activated by ligand-induced conformational changes. We quantified the dimerization of three …

The protein tyrosine kinase JAK2 mediates signaling through numerous cytokine receptors.
JAK2 possesses a pseudokinase domain (JH2) and a tyrosine kinase domain (JH1) …

Abstract Janus kinase-2 (JAK2) mediates signaling by various cytokines, including
erythropoietin and growth hormone. JAK2 possesses tandem pseudokinase and tyrosine …

The availability of protein measurements and whole exome sequence data in the UK
Biobank enables investigation of potential observational and genetic protein-cancer risk …

Pseudokinases lack conserved motifs typically required for kinase activity. Nearly half of
pseudokinases bind ATP, but only few retain phosphotransfer activity, leaving the functional …

The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2
decades ago, but identification of mutations in the pseudokinase domain of JAK2 in …

The V617F mutation in the Jak2 pseudokinase domain causes myeloproliferative
neoplasms, and the equivalent mutation in Jak1 (V658F) is found in T-cell leukemias …

The Janus kinase (JAK) proteins are a family of intracellular nonreceptor tyrosine kinases
involved in cytokine signaling via the JAK–STAT (signal transducers and activators of …