The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

Acute cardiomyocyte necrosis in the infarcted heart generates damage-associated
molecular patterns, activating complement and toll-like receptor/interleukin-1 signaling, and …

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality,
it is crucial that we understand the molecular pathophysiological mechanisms at play …

With the incidence and impact of atherosclerotic cardiovascular disease and its clinical
manifestations still rising, therapeutic options that target the causal mechanisms of this …

After acute myocardial infarction, ventricular remodeling is characterized by changes at the
molecular, structural, geometrical and functional level that determine progression to heart …

Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic
cytokine with critical and supporting roles in many disease states and conditions. Its disease …

Mitophagy is a selective form of autophagy in which damaged or dysfunctional mitochondria
are specifically targeted by autophagosomes for lysosomal degradation. Studies have …

Objective: Monocyte infiltration is a critical step in the pathophysiology of plaque instability in
coronary artery disease (CAD). Macrophage migration inhibitory factor (MIF) is involved in …

Dysregulation of innate immune responses can result in chronic inflammatory conditions.
Glucocorticoids, the current frontline therapy, are effective immunosuppressive drugs but …

Introduction: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with
chemokine-like functions that increasingly is being studied in different aspects of …