Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …

ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against
xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance …

ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to
multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …

Two ATP-binding cassette transporters, ABCB1/MDR1 and ABCG2/BCRP, are considered
the most critical determinants for chemoresistance in hepatocellular carcinoma. However …

5-Aminolevulinic acid (ALA) is a naturally occurring amino acid synthesized in all nucleated
mammalian cells. As a porphyrin precursor, ALA is metabolized in the heme biosynthetic …

Multitarget datasets that correlate bioactivity landscapes of small-molecules toward different
related or unrelated pharmacological targets are crucial for novel drug design and …