Permeability Benchmarking: Guidelines for Comparing in Silico, in Vitro, and in Vivo Measurements
Permeability is a measure of the degree to which cells can transport molecules across
biological barriers. Units of permeability are distance per unit time (typically cm/s), where …
biological barriers. Units of permeability are distance per unit time (typically cm/s), where …
Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
JYP Koh, Y Itahana, A Krah, H Mostafa, M Ong… - Communications …, 2024 - nature.com
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and
patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter …
patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter …
Coupling the role of lipids to the conformational dynamics of the ABC transporter P-glycoprotein
D De Vecchis, LV Schäfer - Biophysical Journal, 2024 - cell.com
The ATP-binding cassette transporter P-glycoprotein (P-gp) is a multidrug efflux pump that is
overexpressed in a variety of cancers and associated with the drug-resistance phenomenon …
overexpressed in a variety of cancers and associated with the drug-resistance phenomenon …