Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Chromanone or Chroman-4-one is the most important and interesting heterobicyclic
compound and acts as a building block in medicinal chemistry for isolation, designing and …

The chroman-4-one framework is a significant structural entity that belongs to the class of
oxygen-containing heterocycles. It acts as a major building block in a large class of …

In accordance with WHO statistics, leishmaniasis is one of the top neglected tropical
diseases, affecting around 700 000 to one million people per year. To that end, a new series …

Abstract Pteridine reductase 1 (PTR1) is a catalytic protein belonging to the folate metabolic
pathway in Trypanosmatidic parasites. PTR1 is a known target for the medicinal chemistry …

Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …

Parasitic diseases remain as unresolved health issues worldwide. While for some parasites
the treatments involve drug combinations with serious side effects, for others, chemical …

Tropical, vector-borne, and neglected diseases with a limited number of medication
therapies include Leishmaniasis, Malaria, Chagas and Human African Trypanosomiasis …

Leishmaniasis is endemic in at least 98 countries. Due to the high toxicity and resistance
associated with the drugs, we chose lignans as an alternative, due to their favorable …

Introduction Trypanosomatidic parasitic infections in humans and animals caused by
Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species pose a significant health …