Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons
in the mammalian cortex and are characterized by dense wiring into the local network and …

Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition.
Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping …

γ-Aminobutyric acid (GABA) ergic inputs are strategically positioned to gate synaptic
integration along the dendritic arbor of pyramidal cells. However, their spatiotemporal …

γ-frequency oscillations (30-120 Hz) in cortical networks influence neuronal encoding and
information transfer, and are disrupted in multiple brain disorders. While synaptic inhibition …

GABAergic interneurons, which are highly diverse, have long been thought to contribute to
the timing of neural activity as well as to the generation and shaping of brain rhythms …

Neurons and neural networks often extend hundreds of micrometers in three dimensions.
Capturing the calcium transients associated with their activity requires volume imaging …