The E-cadherin-catenin complex plays a crucial role in epithelial cell cell adhesion and in
the maintenance of tissue architecture. Down-regulation of E-cadherin expression correlates …

The contribution of molecular genetics to colorectal cancer has been largely restricted to
relatively rare inherited tumours and to the detection of germ line mutations predisposing to …

Specific human papilloma virus (HPV) types appear to be necessary etiological factors for
most cervical cancers, yet additional genetic alterations seem to be required for their …

The DiFi human colorectal cancer cell line was recently established from a familial
adenomatous polyposis patient with extracolonic features characteristic of the Gardner …

Colorectal cancer remains a major health problem. Few therapies are effective apart from
surgery, and survival has increased little in recent years. This is despite the fact that …

Ototoxicity remains a major dose-limiting side effect of cisplatin. The current studies were
carried out to evaluate the effectiveness of a novel Src-protein tyrosine kinase inhibitor in …

Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a
variety of malignant neoplasms. The relationship between LOH and established …

Various genetic alterations in ulcerative colitis (UC)-associated colorectal cancers (CRCs)
have been reported. However, almost all studies have shown abnormalities of the known …

The contribution of molecular genetics to colorectal cancer has been restricted largely to
relatively rare inherited tumours and to the detection of germline mutations predisposing to …

Hereditary intestinal cancers mainly occur in the framework of the familial adenomatous
polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) syndromes …