CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

Insulin secretion is a highly dynamic process regulated by various factors including
nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied …

Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …

Luminal acidification is of pivotal importance for the physiology of the secretory and
endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V …

The cause of insulin insufficiency remains unknown in many diabetic cases. Up to 50% adult
patients with cystic fibrosis (CF), a disease caused by mutations in the gene encoding the …

The insulin granule was previously thought of as merely a container, but accumulating
evidence suggests that it also acts as a signaling node. Regulatory pathways intersect at but …

Neuronal ceroid lipofuscinoses (NCLs) are a group of autosomal recessive lysosomal
storage diseases. One variant form of late-infantile NCL (vLINCL) is caused by mutations of …

Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …