Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank
Abstract Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array
genotyping with imputation (IMP) are common strategies for assessing genetic variation and …
genotyping with imputation (IMP) are common strategies for assessing genetic variation and …
Fast variance component analysis using large-scale ancestral recombination graphs
J Zhu, G Kalantzis, A Pazokitoroudi, ÁF Gunnarsson… - bioRxiv, 2024 - biorxiv.org
Recent algorithmic advancements have enabled the inference of genome-wide ancestral
recombination graphs (ARGs) from genomic data in large cohorts. These inferred ARGs …
recombination graphs (ARGs) from genomic data in large cohorts. These inferred ARGs …
Computationally efficient meta-analysis of gene-based tests using summary statistics in large-scale genetic studies
Meta-analysis of gene-based tests using single variant summary statistics is a powerful
strategy for associating genes with disease. However, current approaches require sharing …
strategy for associating genes with disease. However, current approaches require sharing …