[HTML][HTML] Immunogenetics of autism spectrum disorder: a systematic literature review

M Arenella, R Matuleviciute, R Tamouza… - Brain, Behavior, and …, 2023 - Elsevier
The aetiology of autism spectrum disorder (ASD) is complex and, partly, accounted by
genetic factors. Nonetheless, the genetic underpinnings of ASD are poorly defined. The …

Re-emerging concepts of immune dysregulation in autism spectrum disorders

A Erbescu, SM Papuc, M Budisteanu, A Arghir… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
communication and social interaction deficits, and by restricted interests and stereotyped …

Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

MS Ivraghi, MY Zamanian, R Gupta… - CNS Neuroscience …, 2024 - Wiley Online Library
Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α,
a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower …

[HTML][HTML] Interleukin-38 in health and disease

DM de Graaf, LU Teufel, LAB Joosten, CA Dinarello - Cytokine, 2022 - Elsevier
This review examines the role of interleukin (IL)-38 in health and disease. IL-38 functions as
an anti-inflammatory cytokine in the IL-1 family, with properties comparable to IL-37, another …

[HTML][HTML] Loss of interleukin 1 signaling causes impairment of microglia-mediated synapse elimination and autistic-like behaviour in mice

A Borreca, C Mantovani, G Desiato, I Corradini… - Brain, Behavior, and …, 2024 - Elsevier
In the last years, the hypothesis that elevated levels of proinflammatory cytokines contribute
to the pathogenesis of neurodevelopmental diseases has gained popularity. IL-1 is one of …

Discovery of a novel cytokine signature for the diagnosis of autism spectrum disorder in young Arab children in Qatar

W Nour-Eldine, NPA Manaph, SM Ltaief… - Frontiers in …, 2024 - frontiersin.org
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental
disorder characterized by impaired social interaction and communication and the …

Impairment in the intestinal morphology and in the immunopositivity of toll-like receptor-4 and other proteins in an autistic mouse model

C Franco, M Gianò, G Favero, R Rezzani - International journal of …, 2022 - mdpi.com
Autism spectrum disorder (ASD) identifies a neurodevelopmental disease defined by social
impairments and repetitive or stereotyped behaviors. The etiology of ASD remains unclear; it …

Psychobiotics improve propionic acid-induced neuroinflammation in juvenile rats, rodent model of autism

M Alonazi, A Ben Bacha, A Al Suhaibani… - Translational …, 2022 - degruyter.com
This study aimed to evaluate the protective and therapeutic potency of bee pollen and
probiotic mixture on brain intoxication caused by propionic acid (PPA) in juvenile rats. Five …

Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool

A Fucic, A Mantovani, J Vena, MS Bloom, N Sincic… - Reproductive …, 2023 - Elsevier
Diet has long been known to modify physiology during development and adulthood.
However, due to a growing number of manufactured contaminants and additives over the …

In search of immune cellular sources of abnormal cytokines in the blood in autism spectrum disorder: A systematic review of case-control studies

W Nour-Eldine, SM Ltaief, NP Abdul Manaph… - Frontiers in …, 2022 - frontiersin.org
Abnormal cytokine levels in circulating blood have been repeatedly reported in autism;
however, the underlying cause remains unclear. This systematic review aimed to investigate …