Deep learning in drug discovery: an integrative review and future challenges

H Askr, E Elgeldawi, H Aboul Ella… - Artificial Intelligence …, 2023 - Springer
Recently, using artificial intelligence (AI) in drug discovery has received much attention
since it significantly shortens the time and cost of developing new drugs. Deep learning (DL) …

Deep learning: new computational modelling techniques for genomics

G Eraslan, Ž Avsec, J Gagneur, FJ Theis - Nature Reviews Genetics, 2019 - nature.com
As a data-driven science, genomics largely utilizes machine learning to capture
dependencies in data and derive novel biological hypotheses. However, the ability to extract …

Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

Deep learning in bioinformatics

S Min, B Lee, S Yoon - Briefings in bioinformatics, 2017 - academic.oup.com
In the era of big data, transformation of biomedical big data into valuable knowledge has
been one of the most important challenges in bioinformatics. Deep learning has advanced …

[HTML][HTML] On the road to explainable AI in drug-drug interactions prediction: A systematic review

TH Vo, NTK Nguyen, QH Kha, NQK Le - Computational and Structural …, 2022 - Elsevier
Over the past decade, polypharmacy instances have been common in multi-diseases
treatment. However, unwanted drug-drug interactions (DDIs) that might cause unexpected …

Applications of deep learning in biomedicine

P Mamoshina, A Vieira, E Putin… - Molecular …, 2016 - ACS Publications
Increases in throughput and installed base of biomedical research equipment led to a
massive accumulation of-omics data known to be highly variable, high-dimensional, and …

DeepInsight: A methodology to transform a non-image data to an image for convolution neural network architecture

A Sharma, E Vans, D Shigemizu, KA Boroevich… - Scientific reports, 2019 - nature.com
It is critical, but difficult, to catch the small variation in genomic or other kinds of data that
differentiates phenotypes or categories. A plethora of data is available, but the information …

The next era: deep learning in pharmaceutical research

S Ekins - Pharmaceutical research, 2016 - Springer
Over the past decade we have witnessed the increasing sophistication of machine learning
algorithms applied in daily use from internet searches, voice recognition, social network …

Deep learning in omics: a survey and guideline

Z Zhang, Y Zhao, X Liao, W Shi, K Li… - Briefings in functional …, 2019 - academic.oup.com
Omics, such as genomics, transcriptome and proteomics, has been affected by the era of big
data. A huge amount of high dimensional and complex structured data has made it no …

The Kipoi repository accelerates community exchange and reuse of predictive models for genomics

Ž Avsec, R Kreuzhuber, J Israeli, N Xu, J Cheng… - Nature …, 2019 - nature.com
12. Assisted Human Reproduction Act, SC 2004. http://laws-lois. justice. gc. ca/PDF/A-13.4.
pdf (2018) 13. CNN. Rael defends claims of cloned baby. http://www. cnn. com/2003 …