Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

The hallmarks of cancer metabolism: Still emerging

NN Pavlova, J Zhu, CB Thompson - Cell metabolism, 2022 - cell.com
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Slow TCA flux and ATP production in primary solid tumours but not metastases

CR Bartman, DR Weilandt, Y Shen, WD Lee, Y Han… - Nature, 2023 - nature.com
Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …

What is cancer metabolism?

LWS Finley - Cell, 2023 - cell.com
The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Regulation and function of the mammalian tricarboxylic acid cycle

PK Arnold, LWS Finley - Journal of Biological Chemistry, 2023 - ASBMB
The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

[HTML][HTML] Lactate activates the mitochondrial electron transport chain independently of its metabolism

X Cai, CP Ng, O Jones, TS Fung, KW Ryu, D Li… - Molecular cell, 2023 - cell.com
Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

CD8+ T cell metabolism in infection and cancer

M Reina-Campos, NE Scharping… - Nature Reviews …, 2021 - nature.com
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism

I Elia, MC Haigis - Nature metabolism, 2021 - nature.com
Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Lactate: the ugly duckling of energy metabolism

JD Rabinowitz, S Enerbäck - Nature metabolism, 2020 - nature.com
Lactate, perhaps the best-known metabolic waste product, was first isolated from sour milk,
in which it is produced by lactobacilli. Whereas microbes also generate other fermentation …

Cellular adaptation to hypoxia through hypoxia inducible factors and beyond

P Lee, NS Chandel, MC Simon - Nature reviews Molecular cell biology, 2020 - nature.com
Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …