Background: In preconception and pregnancy, women are encouraged to take folic acid-
based supplements over and above food intake. The upper tolerable limit of folic acid is …

Major depressive disorder (MDD) is a complex and common disorder, with many factors
involved in its onset and development. The clinical management of this condition is …

The role of folate, in its synthetic and bioactive form, as an in utero modifier of metabolic
outcomes in mothers and offspring is examined in this review. During pregnancy, a …

The nutritional management of depression has long been discussed, due to the perceived
benefit of a nutritional product having less side effects than pharmaceutical agents …

Objectives This is a meta-analysis of randomized controlled trials (RCTs) to examine the
efficacy and safety of adjunctive folate for three major mental disorders (schizophrenia …

Mood disorders affect more than 500 million people around the world. In the last decade,
their prevalence has increased, and many people suffer from nervousness, anxiety, and …

Supplementation with [6S]-5-methyltetrahydrofolic acid (MTHF) is recommended as an
alternative to folic acid (FA) in prenatal supplements. This study compared equimolar …

Background Over 48.5 million couples are reported with infertility worldwide. Health policy
recommends folic acid in women of childbearing age, particularly in preconception and …

[6 S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in
diets and prenatal supplements. This study compared the effects of these two forms on …

Depression is a heterogeneous disorder with a wide range of presentations. Most patients
with depression are seen in primary care, where it is often unrecognized; thus, screening for …