Background Why some individuals develop AIDS rapidly whereas others remain healthy
without treatment for many years remains a central question of HIV research. Of the …

Phylodynamics has become an increasingly popular statistical framework to extract
evolutionary and epidemiological information from pathogen genomes. By harnessing such …

Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …

Human immunodeficiency virus type 1 (HIV-1) is pandemic, but its contemporary global
transmission network has not been characterized. A better understanding of the properties …

Background HIV evolves rapidly at the epidemiological level but also at the within-host level.
The virus' within-host evolutionary rates have been argued to be much higher than its …

Phylogenetics is an important tool for HIV research, and offers opportunities to understand
critical aspects of the HIV epidemic. Like all epidemiological research, the methods used …

Influenza viruses rapidly diversify within individual human infections. Several recent studies
have deep-sequenced clinical influenza infections to identify viral variation within hosts, but …

Efficient and effective HIV prevention measures for generalized epidemics in sub-Saharan
Africa have not yet been validated at the population level. Design and impact evaluation of …

The Human Immunodeficiency Virus (HIV) is one of the most threatening viral agents. This
virus infects approximately 33 million people, many of whom are unaware of their status …

Transmission lies at the interface of human immunodeficiency virus type 1 (HIV-1) evolution
within and among hosts and separates distinct selective pressures that impose differences …