Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications

M Haack, N Simpson, N Sethna, S Kaur… - …, 2020 - nature.com
Pain can be both a cause and a consequence of sleep deficiency. This bidirectional
relationship between sleep and pain has important implications for clinical management of …

Early evidence of the impact of cannabis legalization on cannabis use, cannabis use disorder, and the use of other substances: Findings from state policy evaluations

R Smart, RL Pacula - The American journal of drug and alcohol …, 2019 - Taylor & Francis
Background: The past decade has seen unprecedented shifts in the cannabis policy
environment, and the public health impacts of these changes will hinge on how they affect …

[HTML][HTML] Cannabinoids and pain: new insights from old molecules

S Vučković, D Srebro, KS Vujović, Č Vučetić… - Frontiers in …, 2018 - frontiersin.org
Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …

Cannabinoid delivery systems for pain and inflammation treatment

N Bruni, C Della Pepa, S Oliaro-Bosso, E Pessione… - Molecules, 2018 - mdpi.com
There is a growing body of evidence to suggest that cannabinoids are beneficial for a range
of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms …

Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …

EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

G Donvito, SR Nass, JL Wilkerson, ZA Curry… - …, 2018 - nature.com
A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …

[HTML][HTML] Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study

G Campbell, WD Hall, A Peacock, N Lintzeris… - The Lancet Public …, 2018 - thelancet.com
Background Interest in the use of cannabis and cannabinoids to treat chronic non-cancer
pain is increasing, because of their potential to reduce opioid dose requirements. We aimed …

Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis …

EP Baron, P Lucas, J Eades, O Hogue - The journal of headache and pain, 2018 - Springer
Background Medicinal cannabis registries typically report pain as the most common reason
for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and …

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies

S Nielsen, L Picco, B Murnion, B Winters… - …, 2022 - nature.com
Cannabinoid co-administration may enable reduced opioid doses for analgesia. This
updated systematic review on the opioid-sparing effects of cannabinoids considered …

Benefits and harms of medical cannabis: a scoping review of systematic reviews

M Pratt, A Stevens, M Thuku, C Butler, B Skidmore… - Systematic reviews, 2019 - Springer
Background There has been increased interest in the role of cannabis for treating medical
conditions. The availability of different cannabis-based products can make the side effects of …