Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is a chronic inflammatory disorder of the gastrointestinal tract. Although the …

Insect gut microbiota plays important roles in acquiring nutrition, preventing pathogens
infection, modulating immune responses, and communicating with environment. Gut …

Irinotecan (CPT-11)-induced gastrointestinal toxicity strongly limits its anticancer efficacy.
Glycyrrhiza uralensis Fisch., especially flavonoids, has strong anti-inflammatory and …

Inflammatory bowel disease (IBD), which include Crohn's disease (CD) and ulcerative colitis
(UC), exhibits a complex multifactorial pathogenesis involving genetic susceptibility …

The number of people who smoke has increased in recent years, and the incidence of
smoking-related diseases increases annually. This study was conducted to explore whether …

Rectal prolapse in serious inflammatory bowel disease is caused by abnormal reactions of
the intestinal mucosal immune system. The circadian clock has been implicated in immune …

Background The conversion of primary bile acids to secondary bile acids by the gut
microbiota has been implicated in colonic inflammation. This study investigated the role of …

The gut epithelial barrier provides the first line of defense protecting the internal milieu from
the environment. To circumvent the exposure to constant challenges such as pathogenic …

Dysregulated cytokine signalling is a hallmark of inflammatory bowel diseases. Inflammatory
responses of the colon are regulated by the suppressor of cytokine signalling (SOCS) …

Background Mutations in ITCH, which encodes an E3 ubiquitin-protein ligase, can result in
systemic autoimmunity and immunodeficiency. The clinical phenotype and mechanism of …