Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

Idiopathic pulmonary fibrosis is characterized by radiographically evident interstitial
infiltrates predominantly affecting the lung bases and by progressive dyspnea and …

Rationale: Animal and human studies support the importance of the coagulation cascade in
pulmonary fibrosis. Objectives: In a cohort of subjects with progressive idiopathic pulmonary …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology
with a variable and unpredictable course. Objectives: The aim of this study was to identify …

Despite its disadvantages, the bleomycin animal model remains the best available
experimental tool for studying disease pathogenesis and testing of novel pharmaceutical …

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by
progressive fibrosis of the alveolar interstitium. The pathogenesis is thought to involve …

Introduction Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is
characterized by chronic and progressive fibrosing interstitial pneumonia which …

Ferroptosis is a new form of regulated cell death. Fibroblast-to-myofibroblast differentiation is
known to be involved in the pathogenesis of idiopathic pulmonary fibrosis. Utilizing HFL1 …

Background Oral acetylcysteine (also known as N-acetylcysteine) is used with pirfenidone to
treat idiopathic pulmonary fibrosis (IPF) in Europe. However, no randomised studies have …